Pax genes play key roles in the formation of tissues and organs during embryogenesis. Pax3 and Pax7 mark myogenic progenitor cells and regulate their behavior and their entry into the program of skeletal muscle differentiation. Recent results have underlined the importance of the Pax3/7 population of cells for skeletal muscle development and regeneration. We present our current understanding of different aspects of Pax3/7 function in myogenesis, focusing on the mouse model. This is compared with that of other Pax proteins in the emergence of tissue specific lineages and their differentiation as well as in cell survival, proliferation, and migration. Finally, we consider the molecular mechanisms that underlie the function of Pax transcription factors, including the cofactors and regulatory networks with which they interact.

中文翻译：

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Pax基因在组织和器官发育中的作用：Pax3和Pax7调节肌肉祖细胞功能。

Pax基因在胚胎发生过程中的组织器官形成中起关键作用。Pax3和Pax7标记成肌祖细胞，并调节其行为并进入骨骼肌分化程序。最近的结果强调了Pax3 / 7细胞群对骨骼肌发育和再生的重要性。我们目前对Pax3 / 7在肌发生中功能不同方面的理解，重点是小鼠模型。在组织特异性谱系的出现及其分化以及细胞存活，增殖和迁移方面，可以将其与其他Pax蛋白进行比较。最后，我们考虑了Pax转录因子功能的分子机制，包括它们相互作用的辅因子和调控网络。