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Morphogenesis in Candida albicans.
Annual Review of Microbiology ( IF 10.5 ) Pub Date : 2007-05-18 , DOI: 10.1146/annurev.micro.61.080706.093341
Malcolm Whiteway 1 , Catherine Bachewich
Affiliation  

Candida albicans is termed a dimorphic fungus because it proliferates in either a yeast form or a hyphal form. The switch between these forms is the result of a complex interplay of external and internal factors and is coordinated in part by polarity-regulating proteins that are conserved among eukaryotic cells. However, yeast and hyphal cells are not the only morphological states of C. albicans. The opaque form required for mating, the pseudohyphal cell, and the chlamydospore represent distinct cell types that form in response to specific genetic or environmental conditions. In addition, hyperextended buds can form as a result of various cell cycle-related stresses. Recent studies are beginning to shed light on some of the molecular controls regulating the various morphogenetic forms of this fascinating human pathogen.

中文翻译:

白色念珠菌的形态发生。

白色念珠菌因其以酵母形式或菌丝形式增殖而被称为双态真菌。这些形式之间的转换是外部和内部因素复杂相互作用的结果,并且在一定程度上由真核细胞中保守的极性调节蛋白协调。但是,酵母和菌丝细胞并不是白色念珠菌的唯一形态。交配所需的不透明形式,假菌丝细胞和衣原体代表不同的细胞类型,这些细胞类型是对特定遗传或环境条件的响应而形成的。此外,由于各种细胞周期相关的压力,可能会形成过度伸展的芽。最近的研究开始阐明调节这种引人入胜的人类病原体各种形态发生形式的某些分子控制。
更新日期:2019-11-01
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