当前位置: X-MOL 学术Annu. Rev. Genomics Hum. Genet. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Annotating noncoding RNA genes.
Annual Review of Genomics and Human Genetics ( IF 8.7 ) Pub Date : 2007-05-18 , DOI: 10.1146/annurev.genom.8.080706.092419
Sam Griffiths-Jones 1
Affiliation  

Noncoding RNA genes produce a functional RNA product rather than a translated protein. More than 1500 homologs of known "classical" RNA genes can be annotated in the human genome sequence, and automatic homology-based methods predict up to 5000 related sequences. Methods to predict novel RNA genes on a whole-genome scale are immature at present, but their use hints at tens of thousands of such genes in the human genome. Messenger RNA-like transcripts with no protein-coding potential are routinely discovered by high-throughput transcriptome analyses. Meanwhile, various experimental studies have suggested that the vast majority of the human genome is transcribed, although the proportion of the detected RNAs that is functional remains unknown.

中文翻译:

注释非编码RNA基因。

非编码RNA基因产生功能性RNA产物,而不是翻译的蛋白质。可以在人类基因组序列中注释超过1500个已知的“经典” RNA基因的同源物,并且基于自动同源性的方法可以预测多达5000个相关序列。目前,在全基因组规模上预测新型RNA基因的方法尚不成熟,但它们的使用暗示着人类基因组中成千上万的此类基因。高通量转录组分析通常发现没有蛋白编码潜能的信使RNA样转录物。同时,各种实验研究表明,尽管检测到的具有功能的RNA的比例仍是未知的,但人类基因组的绝大多数仍被转录。
更新日期:2019-11-01
down
wechat
bug