In humans, genetic factors have long been suspected to contribute to the onset and outcome of tuberculosis. Such effects are difficult to identify owing to their complex inheritance, and to the confounding impact of environmental factors, notably pathogen-associated virulence determinants. Recently, forward genetic approaches in mouse models and in human populations have been used to elucidate a molecular basis for predisposition to mycobacterial diseases. The genetic dissection of host predisposition to infection with Mycobacterium bovis BCG and M. tuberculosis will help to define the key molecules involved in host antituberculous immunity and should provide new insights into this important infectious disease.

中文翻译：

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小鼠和男性中分枝杆菌疾病的宿主遗传学：卡介苗病和结核病的正向遗传学研究。

在人类中，长期以来一直怀疑遗传因素会导致结核病的发作和后果。由于其复杂的遗传作用以及环境因素（尤其是病原体相关的毒力决定因素）的混杂影响，难以确定此类影响。最近，在小鼠模型和人群中使用了正向遗传学方法阐明了易患分枝杆菌疾病的分子基础。牛分枝杆菌卡介苗和结核分枝杆菌感染易感宿主的遗传剖析将有助于确定参与宿主抗结核免疫的关键分子，并应提供对该重要传染病的新见解。