The epidermis is a stratified epithelium that functions as a barrier protecting the organism from dehydration, mechanical trauma, and microbial insults. This barrier function is established during embryogenesis through a complex and tightly controlled stratification program. Whereas the morphological changes that occur during epidermal development have been extensively studied, the molecular mechanisms that govern this process remain poorly understood. In this review we summarize the current advances that have been made in understanding the molecular mechanisms that regulate epidermal morphogenesis.

中文翻译：

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调节上皮分层的机制。

表皮是分层的上皮，其作为屏障来保护有机体免于脱水，机械创伤和微生物侵害。通过复杂且严格控制的分层程序，可以在胚胎形成过程中建立这种屏障功能。尽管对表皮发育过程中发生的形态变化已进行了广泛研究，但控制该过程的分子机制仍知之甚少。在这篇综述中，我们总结了了解调节表皮形态发生的分子机制的最新进展。