Epstein-Barr virus (EBV) provides a useful model to study cellular immunity to a genetically stable, persistent human virus. Different sets of proteins expressed during EBV's lytic and cell transforming infections induce qualitatively different cellular immune responses. The factors governing immunodominance hierarchies and the biological effectiveness of these different responses are now being revealed. Analysis of infectious mononucleosis (IM), a clinical syndrome that can arise during primary EBV infection, has allowed the evolution of the responses to be tracked over time, giving an understanding of the immune response kinetics and of those determinants affecting selection into memory. Furthermore, following IM, expression of the receptor for the homeostatic cytokine IL-15 on NK and T cells is lost within these individuals. This experiment of nature provides a system to advance understanding of immunological homeostasis in humans, illustrating how data obtained from the study of EBV have wider significance to the immunological community.

中文翻译：

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人类对病毒感染的细胞反应：来自 Epstein-Barr 病毒的教训。

Epstein-Barr 病毒 (EBV) 提供了一个有用的模型来研究对遗传稳定、持久的人类病毒的细胞免疫。在 EBV 的裂解和细胞转化感染过程中表达的不同蛋白质组诱导质量不同的细胞免疫反应。现在正在揭示控制免疫优势等级的因素和这些不同反应的生物学有效性。对传染性单核细胞增多症 (IM) 的分析是一种可能在原发性 EBV 感染期间出现的临床综合征，它允许随着时间的推移跟踪反应的演变，从而了解免疫反应动力学和影响记忆选择的那些决定因素。此外，在 IM 之后，NK 和 T 细胞上稳态细胞因子 IL-15 受体的表达在这些个体中丢失。