Animals reject diets that lead to indispensable amino acid (IAA) depletion or deficiency. This behavior is adaptive, as continued IAA depletion is incompatible with maintenance of protein synthesis and survival. Following rejection of the diet, animals begin foraging for a better IAA source and develop conditioned aversions to cues associated with the deficient diet. These responses require a sensory system to detect the IAA depletion and alert the appropriate neural circuitry for the behavior. The chemosensor for IAA deprivation is in the highly excitable anterior piriform cortex (APC) of the brain. Recently, the well-conserved general AA control non-derepressing system of yeast was discovered to be activated by IAA deprivation via uncharged tRNA in mammalian APC. This system provides the sensory limb of the mechanism for recognition of IAA depletion that leads to activation of the APC, diet rejection, and subsequent adaptive strategies.

中文翻译：

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必需氨基酸缺乏中的食物摄入抑制机制。

动物拒绝饮食会导致必需的氨基酸（IAA）消耗或缺乏。这种行为是适应性的，因为持续的IAA消耗与维持蛋白质合成和存活不相容。拒绝饮食后，动物开始觅食以获得更好的IAA来源，并对与饮食不足相关的线索产生条件厌恶。这些反应需要一个感觉系统来检测IAA消耗并提醒适当的神经回路进行该行为。用于IAA剥夺的化学传感器位于大脑的高度兴奋性前梨状皮层（APC）中。最近，在哺乳动物APC中，保存良好的一般AA对照非降压酵母系统被IAA剥夺通过不带电荷的tRNA激活。