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Alternative Splicing of Pre-Messenger RNAs in Plants in the Genomic Era
Annual Review of Plant Biology ( IF 23.9 ) Pub Date : 2007-06-01 , DOI: 10.1146/annurev.arplant.58.032806.103754
Anireddy S N Reddy 1
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Primary transcripts (precursor-mRNAs) with introns can undergo alternative splicing to produce multiple transcripts from a single gene by differential use of splice sites, thereby increasing the transcriptome and proteome complexity within and between cells and tissues. Alternative splicing in plants is largely an unexplored area of gene expression, as this phenomenon used to be considered rare. However, recent genome-wide computational analyses have revealed that alternative splicing in flowering plants is far more prevalent than previously thought. Interestingly, pre-mRNAs of many spliceosomal proteins, especially serine/arginine-rich (SR) proteins, are extensively alternatively spliced. Furthermore, stresses have a dramatic effect on alternative splicing of pre-mRNAs including those that encode many spliceosomal proteins. Although the mechanisms that regulate alternative splicing in plants are largely unknown, several reports strongly suggest a key role for SR proteins in spliceosome assembly and regulated splicing. Recent studies suggest that alternative splicing in plants is an important posttranscriptional regulatory mechanism in modulating gene expression and eventually plant form and function.

中文翻译:

基因组时代植物中前信使 RNA 的选择性剪接

带有内含子的初级转录本(前体 mRNA)可以进行选择性剪接,通过差异使用剪接位点从单个基因产生多个转录本,从而增加细胞和组织内部和之间的转录组和蛋白质组的复杂性。植物中的可变剪接在很大程度上是基因表达的一个未探索领域,因为这种现象过去被认为是罕见的。然而,最近的全基因组计算分析表明,开花植物中的选择性剪接比以前认为的要普遍得多。有趣的是,许多剪接体蛋白质的前体 mRNA,尤其是富含丝氨酸/精氨酸 (SR) 的蛋白质,被广泛地选择性剪接。此外,压力对前体 mRNA 的选择性剪接具有显着影响,包括编码许多剪接体蛋白的那些。尽管在植物中调节选择性剪接的机制在很大程度上是未知的,但一些报告强烈表明 SR 蛋白在剪接体组装和调节剪接中的关键作用。最近的研究表明,植物中的选择性剪接是调节基因表达和最终植物形态和功能的重要转录后调控机制。
更新日期:2007-06-01
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