The use of highly active antiretroviral therapy (HAART) has resulted in sustained reductions in mortality from HIV infection. In recent years, HAART has also been associated with metabolic complications that may increase patients' cardiovascular disease risk. Recent studies have begun to support a more complex interaction between HAART, HIV infection itself, and other traditional social and immunologic factors that may predispose patients to premature cardiovascular disease. Substantial progress has been made in the development of newer antiretroviral therapies that have a better metabolic profile with respect to dyslipidemia, hyperglycemia, and lipodystrophy. Optimal selection of metabolically neutral antiretroviral therapies, together with aggressive management of other modifiable coronary risk factors, may improve cardiovascular disease risk in the long term.

中文翻译：

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抗逆转录病毒疗法的心血管风险。

高活性抗逆转录病毒疗法（HAART）的使用已导致HIV感染死亡率的持续降低。近年来，HAART还与代谢并发症相关，可能增加患者心血管疾病的风险。最近的研究已经开始支持HAART，HIV感染本身与其他传统的社会和免疫因素之间的更复杂的相互作用，这些因素可能使患者易患早发性心血管疾病。在开发新的抗逆转录病毒疗法方面已取得了实质性进展，这些疗法在血脂异常，高血糖和脂肪营养不良方面具有更好的代谢特性。最佳选择代谢中性抗逆转录病毒疗法，并积极管理其他可调节的冠心病危险因素，