The death domain (DD) superfamily comprising the death domain (DD) subfamily, the death effector domain (DED) subfamily, the caspase recruitment domain (CARD) subfamily, and the pyrin domain (PYD) subfamily is one of the largest domain superfamilies. By mediating homotypic interactions within each domain subfamily, these proteins play important roles in the assembly and activation of apoptotic and inflammatory complexes. In this chapter, we review the molecular complexes assembled by these proteins, the structural and biochemical features of these domains, and the molecular interactions mediated by them. By analyzing the potential molecular basis for the function of these domains, we hope to provide a comprehensive understanding of the function, structure, interaction, and evolution of this important family of domains.

中文翻译：

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细胞凋亡和炎症细胞内信号传导中的死亡域超家族。

死亡域（DD）超家族包括死亡域（DD）家族，死亡效应域（DED）家族，胱天蛋白酶募集域（CARD）家族和吡啶域（PYD）家族是最大的家族超家族之一。通过介导每个结构域亚家族内的同型相互作用，这些蛋白在凋亡和炎性复合物的组装和激活中起重要作用。在本章中，我们回顾了这些蛋白质组装的分子复合物，这些结构域的结构和生化特征，以及它们介导的分子相互作用。通过分析这些域功能的潜在分子基础，我们希望对这一重要域域的功能，结构，相互作用和进化提供全面的了解。