A new paradigm of matrix metalloproteinase-2 (MMP-2) action in the heart undergoing oxidative stress has emerged. Although best known for its role in the proteolysis of extracellular protein targets, MMP-2 is also localized to the sarcomere within the cardiomyocyte. Oxidative stress activates full-length MMP-2 without need for proteolytic processing and inactivates an endogenous inhibitor, tissue inhibitor of metalloproteinase-4. MMP-2 proteolyzes specific targets within the cell to cause acute, reversible contractile dysfunction. Inhibitors of MMPs are discussed and their possible use for the therapy of acute heart injury caused by oxidative stress is examined.

中文翻译：

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心脏疾病中基质金属蛋白酶2的细胞内靶标：原理和治疗方法。

出现了一种在心脏中遭受氧化应激的基质金属蛋白酶2（MMP-2）作用的新范例。尽管最著名的是MMP-2在细胞外蛋白质靶蛋白水解中的作用，但它也位于心肌细胞的肌节中。氧化应激无需蛋白水解过程即可激活全长MMP-2，并使内源性抑制剂金属蛋白酶4的组织抑制剂失活。MMP-2蛋白水解细胞内的特定靶标，引起急性，可逆的收缩功能障碍。讨论了MMPs抑制剂，并研究了其在氧化应激引起的急性心脏损伤治疗中的可能用途。