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Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer.
Annual Review of Physiology ( IF 18.2 ) Pub Date : 2006-10-14 , DOI: 10.1146/annurev.physiol.69.031905.160319
Carol A Lange 1 , Daniel Gioeli , Stephen R Hammes , Paul C Marker
Affiliation  

Steroid hormone receptors (SRs) are ligand-activated transcription factors and sensors for growth factor-initiated signaling pathways in hormonally regulated tissues, such as the breast or prostate. Recent discoveries suggest that several protein kinases are rapidly activated in response to steroid hormone binding to cytoplasmic SRs. Induction of rapid signaling upon SR ligand binding ensures that receptors and coregulators are appropriately phosphorylated as part of optimal transcription complexes. Alternatively, SR-activated kinase cascades provide additional avenues for SR-regulated gene expression independent of SR nuclear action. We provide an overview of SR and signaling cross talk in breast and prostate cancers, using the human progesterone receptor (PR) and androgen receptor (AR) as models. Kinases are emerging as key mediators of SR action. Cross talk between SR and membrane-initiated signaling events suggests a mechanism for coordinate regulation of gene subsets by mitogenic stimuli in hormonally responsive normal tissues; such cross talk is suspected to contribute to cancer biology.

中文翻译:

快速信号事件与类固醇激素受体作用在乳腺癌和前列腺癌中的整合。

类固醇激素受体(SRs)是配体激活的转录因子,是激素调节组织(如乳房或前列腺)中生长因子启动的信号通路的传感器。最近的发现表明,响应于类固醇激素与细胞质SR的结合,几种蛋白激酶被迅速激活。SR配体结合后快速信号的诱导确保了受体和共调节剂被适当地磷酸化,成为最佳转录复合物的一部分。或者,SR激活的激酶级联反应提供了独立于SR核作用的SR调控基因表达的其他途径。我们使用人类孕激素受体(PR)和雄激素受体(AR)作为模型,概述了乳腺癌和前列腺癌中的SR和信号串扰。激酶正在成为SR行为的关键介体。SR和膜启动信号事件之间的串扰表明激素反应正常组织中有丝分裂刺激协调基因亚群的机制。这种相声被怀疑有助于癌症生物学。
更新日期:2019-11-01
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