In all organisms there is an elevated synthesis of a select family of "stress proteins" in response to a broad array of environmentally driven stress vectors including elevated or depressed temperature, changes in pH, treatment with many classes of chemicals, ischemia, desiccation, and UV irradiation. The presence of stress proteins, often termed heat shock proteins (HSPs), has been recognized for more than four decades, and there is an extensive literature that addresses the structure and properties of HSPs, their function in normal and injured cells and tissues, and the molecular mechanisms of HSP expression in response to stress. Owing to this substantial aggregate of research, there is a growing appreciation of the potential for manipulating the magnitude and timing of elevated HSP expression to achieve targeted therapeutic objectives. The successful realization of this potential requires an understanding of the kinetics of the HSP expression process in response to sublethal stress regimens along with the ability to model the governing events in the process to design practical protocols that could be applied in therapeutic settings. Significant progress has been made in recent years in defining and developing capabilities in these two areas.

中文翻译：

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应激蛋白表达动力学。

在所有生物中，响应各种环境驱动的应激载体（包括升高或降低的温度，pH值变化，用多种化学药品处理，局部缺血，脱水和紫外线照射。应力蛋白（通常称为热激蛋白（HSP））的存在已被识别了四十多年，并且有大量文献涉及HSP的结构和性质，它们在正常细胞和受损细胞和组织中的功能以及热应激表达的分子机制。由于进行了大量的研究，人们越来越认识到操纵HSP表达升高的幅度和时机以实现靶向治疗目标的潜力。要成功实现这一潜力，需要了解HSP表达过程对亚致死应激方案的反应动力学，以及对过程中的调控事件建模的能力，以设计可用于治疗环境的实用方案。近年来，在定义和开发这两个领域的能力方面取得了重大进展。要成功实现这一潜力，需要了解HSP表达过程对亚致死应激方案的反应动力学，以及对过程中的调控事件建模的能力，以设计可用于治疗环境的实用方案。近年来，在定义和开发这两个领域的能力方面取得了重大进展。要成功实现这一潜力，需要了解HSP表达过程对亚致死应激方案的反应动力学，以及对过程中的调控事件建模的能力，以设计可用于治疗环境的实用方案。近年来，在定义和开发这两个领域的能力方面取得了重大进展。