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Actin-related proteins localized in the nucleus: from discovery to novel roles in nuclear organization
Nucleus ( IF 3.7 ) Pub Date : 2011-01-01 , DOI: 10.4161/nucl.2.1.14510
Yukako Oma 1 , Masahiko Harata
Affiliation  

The actin family consists of conventional actin and actin-related proteins (ARPs), and the members show moderate similarity and share the same basal structure. Following the finding of various ARPs in the cytoplasm in the 1990s, multiple subfamilies that are localized predominantly in the nucleus were identified. Consistent with these cytological observations, subsequent biochemical analyses revealed the involvement of the nuclear ARPs in ATP-dependent chromatin-remodeling and histone acetyltransferase complexes. In addition to their contribution to chromatin remodeling, recent studies have shown that nuclear ARPs have roles in the organization of the nucleus that are independent of the activity of the above-mentioned complexes. Therefore, nuclear ARPs are recognized as novel key regulators of genome function, and affect not only the remodeling of chromatin but also the spatial arrangement and dynamics of chromatin within the nucleus.

中文翻译:

位于细胞核中的肌动蛋白相关蛋白:从发现到在核组织中的新作用

肌动蛋白家族由常规肌动蛋白和肌动蛋白相关蛋白 (ARPs) 组成,成员表现出适度的相似性并共享相同的基础结构。在 1990 年代在细胞质中发现各种 ARP 之后,鉴定了主要位于细胞核中的多个亚家族。与这些细胞学观察一致,随后的生化分析揭示了核 ARPs 参与了 ATP 依赖性染色质重塑和组蛋白乙酰转移酶复合物。除了对染色质重塑的贡献外,最近的研究表明,核 ARPs 在细胞核的组织中具有作用,这些作用与上述复合物的活性无关。因此,核 ARPs 被认为是基因组功能的新型关键调节因子,
更新日期:2011-01-01
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