In this computational study we consider a generalized minimal model structure for the intravenously infused insulin–blood glucose dynamics, which can represent a wide variety of diabetic patients, and augment this model structure with a glucose rate disturbance signal that captures the aggregate effects of various internal and external factors on blood glucose. Then we develop a model‐based, switching controller, which attempts to balance between optimal performance, reduced computational complexity and avoidance of dangerous hypoglycaemic events. We evaluate the proposed algorithm relative to the widely studied proportional—derivative controller for the regulation of blood glucose with continuous insulin infusions. The results show that the proposed switching control strategy can regulate blood glucose much better than the proportional—derivative controller for all the different types of diabetic patients examined. This new algorithm is also shown to be remarkably robust in the event of concurrent, unknown variations in critical parameters of the adopted model. Copyright © 2009 John Wiley & Sons, Ltd.

中文翻译：

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一种降低血糖紊乱的切换控制策略。

在这项计算研究中，我们考虑了静脉输注胰岛素 - 血糖动态的广义最小模型结构，它可以代表各种各样的糖尿病患者，并用葡萄糖率干扰信号增强该模型结构，该信号捕获各种内部以及影响血糖的外在因素。然后我们开发了一个基于模型的开关控制器，它试图在最佳性能、降低计算复杂度和避免危险的低血糖事件之间取得平衡。我们相对于广泛研究的用于通过连续胰岛素输注调节血糖的比例微分控制器来评估所提出的算法。结果表明，对于所检查的所有不同类型的糖尿病患者，所提出的开关控制策略可以比比例微分控制器更好地调节血糖。在所采用模型的关键参数发生并发、未知变化的情况下，这种新算法也表现出非常强大的鲁棒性。版权所有 © 2009 John Wiley & Sons, Ltd.