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Extra views on RNA-dependent DNA methylation and MBD6-dependent heterochromatin formation in nucleolar dominance
Nucleus ( IF 3.7 ) Pub Date : 2010-05-01 , DOI: 10.4161/nucl.1.3.11741
Pedro Costa-Nunes 1 , Olga Pontes , Sasha B Preuss , Craig S Pikaard
Affiliation  

Nucleolar dominance is a widespread epigenetic phenomenon, describing the preferential silencing of ribosomal RNA (rRNA) genes inherited from one progenitor of an interspecific hybrid, independent of maternal or paternal effects. In the allotetraploid hybrid plant species Arabidopsis suecica, A. thaliana-derived rRNA genes are silenced whereas the A. arenosa-derived rRNA genes are transcribed. We reported previously on an RNAi-based screen of DNA methyltransferases, methylcytosine binding proteins and RNA-dependent DNA methylation pathway proteins that identified specific activities required for the establishment or enforcement of nucleolar dominance. Here we present additional molecular and cell biological evidence that siRNA-directed cytosine methylation and the methylcytosine binding protein MBD6 bring about large-scale chromosomal effects on rRNA gene loci subjected to nucleolar dominance in A. suecica.

中文翻译:

关于核仁优势中 RNA 依赖性 DNA 甲基化和 MBD6 依赖性异染色质形成的额外观点

核仁优势是一种广泛的表观遗传现象,描述了从种间杂种的一个祖先继承的核糖体 RNA (rRNA) 基因的优先沉默,独立于母本或父本效应。在异源四倍体杂种植物拟南芥中,拟南芥衍生的 rRNA 基因被沉默,而拟南芥衍生的 rRNA 基因被转录。我们之前报道了基于 RNAi 的 DNA 甲基转移酶、甲基胞嘧啶结合蛋白和 RNA 依赖性 DNA 甲基化途径蛋白的筛选,这些蛋白确定了建立或实施核仁优势所需的特定活动。
更新日期:2010-05-01
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