We have recently characterized a novel transmembrane protein of the inner nuclear membrane of mammalian cells. The protein has two very interesting features. First, despite being an integral membrane protein it is able to concentrate in the membranes colocalizing with the mitotic spindle in metaphase and anaphase. Hence, the protein was named Samp1, Spindle associated membrane protein 1. Secondly, it displays a functional connection to centrosomes. This article discusses various aspects of Samp1 in relation to possible cellular function(s).

中文翻译：

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有丝分裂纺锤体中的跨膜内核膜蛋白

我们最近表征了哺乳动物细胞内核膜的一种新型跨膜蛋白。这种蛋白质有两个非常有趣的特征。首先，尽管它是一种完整的膜蛋白，但它能够在中期和后期集中在与有丝分裂纺锤体共定位的膜中。因此，该蛋白质被命名为 Samp1，即纺锤体相关膜蛋白 1。其次，它显示出与中心体的功能连接。本文讨论了 Samp1 与可能的细胞功能相关的各个方面。