In the present communication, we report the fabrication of a unique core-shell inorganic nanomaterial with potential therapeutic and diagnostic functions. It contains an iron–cobalt (FeCo) core that demonstrates magnetic resonance imaging (MRI) contrast property and a thin nanoshell of gold that inhibits the function of a pro-angiogenic growth factor, VEGF165. Au(FeCo) core-shell nanomaterials are fabricated in the gas phase and characterized using transmission electron microscopy, energy dispersive spectrum, inductively coupled plasma analysis, and MRI. Inhibition of VEGF165 function by Au(FeCo) is demonstrated against VEGF165/VPF-induced signaling cascades and proliferation of human umbilical vein endothelial cells (HUVECs). The self-contrast property of Au(FeCo) is determined in vitro by MRI after incubating HUVECs with Au(FeCo), demonstrating intrinsic contrast property of this potentially therapeutic nanomaterial. In brief, we report here the successful fabrication of an inorganic core-shell nanomaterial with potential therapeutic and diagnostic functions. It inhibits the function of VEGF165 and functions as a MRI contrast agent.

中文翻译：

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具有内源性治疗和诊断功能的核壳纳米材料。

在本通讯中，我们报告了一种具有潜在治疗和诊断功能的独特核壳无机纳米材料的制造。它包含一个铁钴 (FeCo) 核，显示出磁共振成像 (MRI) 对比度特性和一个薄的金纳米壳，可抑制促血管生成生长因子 VEGF165 的功能。Au(FeCo) 核壳纳米材料在气相中制备，并使用透射电子显微镜、能量色散谱、电感耦合等离子体分析和 MRI 进行表征。Au(FeCo) 对 VEGF165 功能的抑制被证明可以对抗 VEGF165/VPF 诱导的信号级联反应和人脐静脉内皮细胞 (HUVEC) 的增殖。将 HUVEC 与 Au(FeCo) 一起孵育后，通过 MRI 在体外测定 Au(FeCo) 的自对比特性，展示了这种潜在治疗性纳米材料的内在对比度特性。简而言之，我们在此报告了具有潜在治疗和诊断功能的无机核壳纳米材料的成功制造。它抑制 VEGF165 的功能并作为 MRI 造影剂发挥作用。