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A 3-D Framework for Arterial Growth and Remodeling in Response to Altered Hemodynamics.
International Journal of Engineering Science ( IF 6.6 ) Pub Date : 2010-08-07 , DOI: 10.1016/j.ijengsci.2010.06.033
I Karšaj 1 , J Sorić , J D Humphrey
Affiliation  

We present a three-dimensional mathematical framework for modeling the evolving geometry, structure, and mechanical properties of a representative straight cylindrical artery subjected to changes in mean blood pressure and flow. We show that numerical predictions recover prior findings from a validated two-dimensional framework, but extend those findings by allowing effects of transmural gradients in wall constituents and vasoactive molecules to be simulated directly. Of particular note, we show that the predicted evolution of the residual stress related opening angle in response to an abrupt, sustained increase in blood pressure is qualitatively similar to measured changes when one accounts for a nonlinear transmural distribution of pre-stretched elastin. We submit that continuum-based constrained mixture models of arterial adaptation hold significant promise for deepening our basic understanding of arterial mechanobiology and thus for designing improved clinical interventions to treat many different types of arterial disease and injury.



中文翻译:

响应血流动力学改变的动脉生长和重塑的 3-D 框架。

我们提出了一个三维数学框架,用于对受平均血压和流量变化影响的代表性直圆柱动脉的演化几何、结构和机械特性进行建模。我们表明,数值预测从经过验证的二维框架中恢复了先前的发现,但通过允许直接模拟壁成分和血管活性分子中透壁梯度的影响来扩展这些发现。特别值得注意的是,我们表明,当考虑到预拉伸弹性蛋白的非线性透壁分布时,响应于血压突然、持续增加的残余应力相关张开角的预测演变与测量的变化在性质上相似。

更新日期:2010-08-07
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