Purpose of review: Epidermodysplasia verruciformis has been addressed in depth in the recent literature despite its rarity. The disease is characterized by a persistence in human papillomavirus infections and development of cutaneous malignancies, usually happening more frequently and at a younger age than in the general population. Because of the role of immunodeficiency to viral antigens eventually leading to cancer, EV has become a model for understanding a viral role in cutaneous oncogenesis. Susceptibility loci for EV have been mapped and encoded protein functions are becoming better understood. Discoveries of novel mutations and further study of EV-associated HPV serotypes in lesional and nonlesional skin of affected patients and the general population may help generate a cohesive theory regarding the true role of a defective immune barrier in oncogenesis.

中文翻译：

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疣状表皮发育不良和对 HPV 的易感性。

综述目的：疣状表皮发育不良尽管罕见，但在最近的文献中得到了深入讨论。该疾病的特点是持续存在人乳头瘤病毒感染和皮肤恶性肿瘤，与一般人群相比，通常发生频率更高且年龄更小。由于对病毒抗原的免疫缺陷最终导致癌症的作用，EV 已成为了解病毒在皮肤肿瘤发生中的作用的模型。EV 的易感性位点已经被绘制出来，编码的蛋白质功能也得到了更好的理解。