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Relation between development of cardiovascular disease and the C242T CYBA polymorphism of the NADPH oxidase in ESRD patients.
Disease Markers ( IF 3.464 ) Pub Date : 2010 , DOI: 10.3233/dma-2010-0730
Feng-Ying Tang 1 , Ying Zhu , Gui Hua Wang , Xiong-Wei Xie
Affiliation  

Background: The development of cardiovascular disease in ESRD patients is considered to be associated with oxidative stress. NAD(P)H oxidase has attracted attention as mechanisms of generating oxidative stress. We investigated the relation between the genotype of the C242T CYBA polymorphism of the NADPH oxidase and the development of cardiovascular disease in ESRD patients.Methods: A total of 289 ESRD patients were recruited and allocated to one of the two groups: patients without cardiovascular disease (group N; n=192) and patients developing cardiovascular disease (group D; n=97). The C242T CYBA polymorphism was determined by RFLP-PCR methods.Results: The frequency of the C242T CT+TT genotype was significantly lower in group D than in group N (9.1 vs. 20.2%). In multiple Logistic regression analysis, systolic blood pressure, smoking history and this gene polymorphism were shown to be independent variables for the development of cardiovascular disease in ESRD patients.Conclusions: These results suggest that assessment of the C242T CYBA polymorphism of the NADPH oxidase may be useful in identifying the risk for developing cardiovascular disease in ESRD patients.

中文翻译:

ESRD患者心血管疾病发展与NADPH氧化酶C242T CYBA多态性的关系。

背景:ESRD 患者心血管疾病的发展被认为与氧化应激有关。NAD(P)H氧化酶作为产生氧化应激的机制而受到关注。我们研究了 NADPH 氧化酶的 C242T CYBA 多态性基因型与 ESRD 患者心血管疾病发展之间的关系。方法:总共招募了 289 名 ESRD 患者并分配到两组之一:没有心血管疾病的患者(N 组;n=192)和发生心血管疾病的患者(D 组;n=97)。C242T CYBA 多态性通过RFLP-PCR 方法确定。结果:C242T CT+TT 基因型的频率在 D 组中显着低于 N 组(9.1 对 20.2%)。在多元 Logistic 回归分析中,收缩压、吸烟史和这种基因多态性被证明是 ESRD 患者心血管疾病发展的独立变量。结论:这些结果表明,评估 NADPH 氧化酶的 C242T CYBA 多态性可能有助于确定 ESRD 患者发生心血管疾病的风险。
更新日期:2020-09-25
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