Low-coherence enhanced backscattering (LEBS) is a technique that has recently shown promise for tissue characterization and the detection of early precancer. Although several Monte Carlo models of LEBS have been described, these models have not been accurate enough to predict all of the experimentally observed LEBS features. We present an appropriate Monte Carlo model to simulate LEBS peak properties from polystyrene microsphere suspensions in water. Results show that the choice of the phase function greatly impacts the accuracy of the simulation when the transport mean free path (ls*) is much greater than the spatial coherence length (LSC). When ls* <; LSC, a diffusion-approximation-based model of LEBS is sufficiently accurate. We also use the Monte Carlo model to validate that LEBS can be used to measure the radial scattering probability distribution (radial point spread function), p(r), at small length scales and demonstrate LEBS measurements of p(r ) from biological tissue. In particular, we show that precancerous and benign mucosal tissues have different small length scale light transport properties.

中文翻译：

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具有低相干增强反向散射的亚扩散长度尺度下散射介质中光传输的表征

低相干增强反向散射 (LEBS) 是一项最近显示出用于组织表征和早期癌前病变检测的技术。尽管已经描述了几个 LEBS 的蒙特卡罗模型，但这些模型还不够准确，无法预测所有实验观察到的 LEBS 特征。我们提出了一个合适的蒙特卡罗模型来模拟来自水中聚苯乙烯微球悬浮液的 LEBS 峰值特性。结果表明，当传输平均自由程 (ls*) 远大于空间相干长度 (LSC) 时，相位函数的选择会极大地影响模拟的准确性。当 ls* <; LSC，一种基于扩散近似的 LEBS 模型是足够准确的。我们还使用蒙特卡罗模型来验证 LEBS 可用于在小长度尺度上测量径向散射概率分布（径向点扩散函数）p(r)，并演示生物组织 p(r) 的 LEBS 测量。特别是，我们发现癌前组织和良性粘膜组织具有不同的小长度光传输特性。