Caffeic acid phenethyl ester (CAPE) is a natural product with potent anti-inflammatory, antitumor, and antioxidant activities, and attenuates inflammation and lipid peroxidation. The purpose of the present study was to investigate the effects of CAPE on iron-induced liver damage. Rats were divided into four groups and treated for 7 days with saline (control group), 10 µmol kg CAPE/day s.c. (CAPE group), 50 mg iron-dextran/kg i.p. (IRON group) and CAPE and iron at the same time (IRON+CAPE group). Seven days later, rats were killed and the livers were excised for biochemical analysis. The administration of IRON alone resulted in higher myeloperoxidase (MPO) activity and lipid peroxidation than in the control and CAPE treatment prevented the increase in MPO activity and malondialdeyde (MDA) level. No differences were observed in all four groups with regards to superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities. Our results collectively suggest that CAPE may be an available agent to protect the liver from injury via inhibition of MPO activity.

中文翻译：

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咖啡酸苯乙酯对铁性大鼠肝损伤的保护作用。

咖啡酸苯乙酯 (CAPE) 是一种天然产物，具有强大的抗炎、抗肿瘤和抗氧化活性，可减轻炎症和脂质过氧化。本研究的目的是研究 CAPE 对铁诱导的肝损伤的影响。大鼠分为四组，生理盐水（对照组）、10 μmol kg CAPE/day sc（CAPE组）、50 mg铁-葡聚糖/kg ip（IRON组）和CAPE和铁同时处理7天（IRON+CAPE 组）。7天后，处死大鼠并切下肝脏进行生化分析。与对照相比，单独施用 IRON 导致更高的髓过氧化物酶 (MPO) 活性和脂质过氧化，而 CAPE 治疗阻止了 MPO 活性和丙二醛 (MDA) 水平的增加。在超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GSH-Px) 和过氧化氢酶 (CAT) 活性方面​​，所有四组均未观察到差异。我们的结果共同表明，CAPE 可能是一种有效的药物，可通过抑制 MPO 活性来保护肝脏免受损伤。