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A polymorphism of the corticotropin-releasing hormone receptor 2 (CRHR2) and preterm birth.
Disease Markers ( IF 3.464 ) Pub Date : 2010 , DOI: 10.3233/dma-2010-0681
Maximilian Schmid 1 , Christoph Grimm , Heinz Leipold , Martin Knöfler , Peter Haslinger , Christian Egarter
Affiliation  

Our aim was to investigate whether a genetic variation in the corticotropin-releasing hormone receptor 2 gene might be associated with preterm birth. In this case-control study we evaluated the G/A polymorphism (rs2267717) in intron 2 of the corticotropin-releasing hormone receptor 2 gene in one hundred women with preterm birth and one hundred healthy women with at least one uncomplicated full term pregnancy and no history of preterm birth. No significant correlation was found between the presence of the investigated polymorphism and preterm birth (p = 0.9, odds ratio 0.9 [Confidence interval 0.5–1.7]). A dose dependent association of the investigated polymorphism, in women with preterm birth, with gestational age at delivery (p = 0.003) and birth weight was observed (p = 0.0001). However, no association between IUGR (n=10) with either one of the investigated genotypes (p = 0.3) was found. Stratified analysis within case group (i.e. PPROM vs. non-PPROM) revealed no significant difference in genotype distribution (p = 0.6). In conclusion, the investigated polymorphism does not increase the risk for preterm birth overall but might modulate the length of pregnancy in a dose dependent fashion in a series of Caucasian women.

中文翻译:

促肾上腺皮质激素释放激素受体 2 (CRHR2) 和早产的多态性。

我们的目的是调查促肾上腺皮质激素释放激素受体 2 基因的遗传变异是否可能与早产有关。在这项病例对照研究中,我们评估了 100 名早产妇女和 100 名至少一名无并发症足月妊娠且无并发症的健康妇女的促肾上腺皮质激素释放激素受体 2 基因内含子 2 的 G/A 多态性 (rs2267717)早产史。在所研究的多态性和早产之间没有发现显着相关性(p = 0.9,优势比 0.9 [置信区间 0.5-1.7])。在早产妇女中,所研究的多态性与分娩时的胎龄 ( p = 0.003) 和出生体重之间存在剂量依赖性关联( p= 0.0001)。然而,未发现 IUGR ( n = 10) 与任一研究的基因型 ( p = 0.3)之间存在关联。病例组内的分层分析(即 PPROM 与非 PPROM)显示基因型分布无显着差异(p = 0.6)。总之,研究的多态性总体上不会增加​​早产的风险,但可能会以剂量依赖的方式调节一系列白人妇女的妊娠时间。
更新日期:2020-09-25
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