Intimal hyperplasia due to smooth muscle cell proliferation and migration has been reported to be responsible for the pathogenesis of atherosclerosis and restenosis, manifested following balloon angioplasty. In this study, we employed the balloon angioplasty model to study telomere length regulation in proliferating vascular smooth muscle cells. Our results showed that balloon angioplasty in iliac arteries resulted in intimal hyperplasia due to proliferation of the smooth muscle cells and small size telomeric restrictional fragments were evident in injured arteries.

中文翻译：

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兔球囊血管成形术后血管平滑肌细胞的端粒限制分析。

据报道，由于平滑肌细胞增殖和迁移引起的内膜增生是动脉粥样硬化和再狭窄的发病原因，在球囊血管成形术后表现出来。在这项研究中，我们采用球囊血管成形术模型来研究增殖血管平滑肌细胞中的端粒长度调节。我们的结果表明，髂动脉球囊血管成形术由于平滑肌细胞的增殖而导致内膜增生，并且在受伤的动脉中明显存在小尺寸的端粒限制性片段。