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Cell separation by non-inertial force fields in microfluidic systems
Mechanics Research Communications ( IF 2.4 ) Pub Date : 2009-01-01 , DOI: 10.1016/j.mechrescom.2008.08.006
Hideaki Tsutsui 1 , Chih-Ming Ho
Affiliation  

Cell and microparticle separation in microfluidic systems has recently gained significant attention in sample preparations for biological and chemical studies. Microfluidic separation is typically achieved by applying differential forces on the target particles to guide them into different paths. This paper reviews basic concepts and novel designs of such microfluidic separators with emphasis on the use of non-inertial force fields, including dielectrophoretic force, optical gradient force, magnetic force, and acoustic primary radiation force. Comparisons of separation performances with discussions on physiological effects and instrumentation issues toward point-of-care devices are provided as references for choosing appropriate separation methods for various applications.

中文翻译:

微流体系统中非惯性力场的细胞分离

微流体系统中的细胞和微粒分离最近在生物和化学研究的样品制备中得到了极大的关注。微流体分离通常是通过在目标粒子上施加不同的力以引导它们进入不同的路径来实现的。本文回顾了此类微流体分离器的基本概念和新颖设计,重点介绍了非惯性力场的使用,包括介电泳力、光学梯度力、磁力和声学初级辐射力。分离性能的比较与生理效应和仪器问题对床旁设备的讨论可作为为各种应用选择合适的分离方法的参考。
更新日期:2009-01-01
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