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The use of immunoglobulin therapy for patients with primary immune deficiency: an evidence-based practice guideline.
Transfusion Medicine Reviews ( IF 4.5 ) Pub Date : 2010-01-09 , DOI: 10.1016/j.tmrv.2009.09.011
Nadine Shehata 1 , Valerie Palda , Tom Bowen , Elie Haddad , Thomas B Issekutz , Bruce Mazer , Robert Schellenberg , Richard Warrington , David Easton , David Anderson , Heather Hume
Affiliation  

The standard treatment for patients with primary antibody deficiency is immunoglobulin (IG), but the care of these patients is complex. These guidelines, initiated by the Canadian Blood Services and the National Advisory Committee on Blood and Blood Products, have been developed to facilitate and standardize the care of these patients by the various physician specialties that are responsible for their care. A panel of national expert immunologists and methodologists developed salient clinical questions; and a systematic, expert, and bibliography literature search up to July 2008 was conducted. One thousand eighty-seven citations were retrieved, and 102 reports were used in the preparation of this guideline. The recommendations provide guidance (1) on the complexity of the treatment of these patients; (2) the established benefits of IG on morbidity and mortality; (3) dosage, routes of administration, and management of reactions; (4) the various IG formulations available; (5) vaccination of these patients; and (6) research priorities.

中文翻译:

免疫球蛋白疗法在原发性免疫缺陷患者中的应用:循证实践指南。

原发性抗体缺乏症患者的标准治疗方法是免疫球蛋白(IG),但这些患者的护理很复杂。这些指南是由加拿大血液服务和国家血液与血液制品咨询委员会发起的,旨在促进和规范负责患者护理的各种医生对患者的护理。由国家免疫专家和方法专家组成的小组提出了重要的临床问题。并进行了系统,专家和参考书目文献检索,直至2008年7月。检索到187篇引文,在准备本指南时使用了102份报告。这些建议提供了指导(1)这些患者治疗的复杂性;(2)IG对发病率和死亡率的既定益处;(3)剂量,给药途径和反应管理;(4)现有的各种中空玻璃配方;(5)这些病人的疫苗接种;(6)研究重点。
更新日期:2019-11-01
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