A comparative framework of memory processes in males with fragile X syndrome (FXS) and Typically Developing (TYP) mental age-match children is presented. Results indicate a divergence in sequencing skills, such that males with FXS recall sequences similarly to TYP children around five and a half years of age, but eth males with FXS recall significantly worse when compared to TYP children around seven and a half years of age. Performance on one working memory measure, an n-back card task, is modeled with a neural network. To date, no network models explicate the sequencing and memory processes in those with FXS. Noise was added to various levels (weight matrices) in the FXS model and outputs approximated human FXS performance. Three models were compared: 1) FXS; 2) younger mental age-TYP matches; and 3) older reading level-TYP matches. Modeling can help to reify conceptualizations of deficits and to guide in the creation of more valid, science-based remediations. The FXS model suggests that the levels of phonological representation and sequencing in memory are candidates for targeted therapies in males with FXS.

中文翻译：

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脆性 X 综合征：排序和记忆的神经网络模型

呈现了患有脆性 X 综合征 (FXS) 和典型发育 (TYP) 心理年龄匹配儿童的男性记忆过程的比较框架。结果表明测序技能存在差异，因此具有 FXS 的男性回忆序列与 5 岁半左右的 TYP 儿童相似，但与 7 岁半左右的 TYP 儿童相比，具有 FXS 的 eth 男性回忆起来要差得多。一个工作记忆测量的表现，一个 n-back 卡任务，是用神经网络建模的。迄今为止，还没有网络模型可以解释 FXS 的排序和记忆过程。噪声被添加到 FXS 模型中的各个级别（权重矩阵），并输出近似于人类 FXS 的表现。三个模型进行了比较：1) FXS；2）年轻的心理年龄-TYP匹配；和 3) 较旧的阅读水平-TYP 匹配。建模有助于具体化缺陷的概念，并指导创建更有效、基于科学的补救措施。FXS 模型表明，记忆中的语音表征和排序水平是 FXS 男性靶向治疗的候选者。