The initiation and progression of cerebral aneurysms are degenerative processes of the arterial wall driven by a complex interaction of biological and hemodynamic factors. Endothelial cells on the artery wall respond physiologically to blood-flow patterns. In normal conditions, these responses are associated with nonpathological tissue remodeling and adaptation. The combination of abnormal blood patterns and genetics predisposition could lead to the pathological formation of aneurysms. Here, we review recent progress on the basic mechanisms of aneurysm formation and evolution, with a focus on the role of hemodynamic patterns.

中文翻译：

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脑动脉瘤的血流动力学

脑动脉瘤的发生和发展是由生物和血液动力学因素复杂相互作用驱动的动脉壁退行性过程。动脉壁上的内皮细胞对血流模式有生理反应。在正常情况下，这些反应与非病理性组织重塑和适应有关。异常血型和遗传倾向的结合可能导致动脉瘤的病理形成。在这里，我们回顾了动脉瘤形成和演变的基本机制的最新进展，重点是血流动力学模式的作用。