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Known mutation (A3072G) in intron 3 of the IGF2 gene is associated with growth and carcass composition in Polish pig breeds.
Journal of Applied Genetics ( IF 2.4 ) Pub Date : 2009 , DOI: 10.1007/bf03195681
M Oczkowicz 1 , M Tyra , K Walinowicz , M Rózycki , B Rejduch
Affiliation  

IGF2 is one of the genes that control muscle development. Moreover,IGF2 is imprinted, as only the paternal allele is expressed in the offspring. Using real-time PCR forIGF2 genotyping (Carrodegous et al. 2005), we evaluated the frequency of theIGF2 A3072G mutation (Van Laere et al. 2003) in pigs: Polish Landrace (PL,N = 271) and Large White (LW,N = 267). Our results are consistent with previous reports, showing that theA allele is common in breeds subjected to strong selection for lean meat content (A allele frequency was 0.79 in LW and 0.69 in PL). Moreover, we compared body composition, growth performance and meat quality traits in pigs carrying opposite genotypes (A/A andG/G) inthe IGF2 gene. The association study revealed that theA allele increases the weight of loin (WL) (additive gene effect = 450±50 g in LW and 213±64g in PL), weight of ham (WH) (544±48 g in LW and 302±72 g in PL), loin eye area (LEA) (4.9±0.46 cm2 in LW and 2.1 ±0.95 cm2 in PL), carcass meat percentage (CP) (3.12±0.27% in LW and 1.89±0.47% in PL), and decreases average backfat thickness (ABF) (−0.2±0.036 cm in LW and −0.2±0.048 cm in PL). Additionally, in PL, theA allele increases the weight of tenderloin (WT) (11±0.01 g), average daily gain (ADG) (30.7±17.29 g), and decreases feed intake (F) (−121±45 g) and days of feeding (DF) (−3.5±2.08 days). No significant effects were observed for meat quality traits. Our results suggest that selection based on theIGF2 mutation in Poland may be very useful in PL and LW pigs, where theG allele is still relatively frequent.

中文翻译:

IGF2 基因内含子 3 中的已知突变 (A3072G) 与波兰猪品种的生长和胴体成分有关。

IGF2是控制肌肉发育的基因之一。此外,IGF2是有印记的,因为只有父本等位基因在后代中表达。使用实时 PCR 进行IGF2基因分型(Carrodegous 等人,2005 年),我们评估了IGF2 A3072G 突变(Van Laere 等人,2003 年)在猪中的频率:波兰长白猪(PL,N = 271)和大白猪(LW , N = 267)。我们的结果与之前的报告一致,表明A等位基因在对瘦肉含量进行强选择的品种中很常见(等位基因频率在 LW 中为 0.79,在 PL 中为 0.69)。此外,我们比较了携带相反基因型的猪的身体成分、生长性能和肉质性状。A/AG/G)IGF2基因中。关联研究表明,A等位基因增加了腰肉 (WL) 的重量(附加基因效应 = LW 中的 450±50 g 和 PL 中的 213±64 g),火腿重量(WH)(LW 中的 544±48 g 和 302 ±72 g in PL),腰眼面积 (LEA)(4.9±0.46 cm 2 in LW 和 2.1 ±0.95 cm 2 in PL),胴体肉百分比(CP)(3.12±0.27% in LW 和 1.89±0.47% in PL) PL),并降低平均背膘厚度 (ABF)(LW 为 -0.2±0.036 cm,PL 为 -0.2±0.048 cm)。此外,在 PL 中,A等位基因增加里脊肉的重量 (WT) (11±0.01 g)、平均日增重 (ADG) (30.7±17.29 g),并减少采食量 (F) (-121±45 g) 和饲养天数 (DF) (-3.5±2.08 天)。对肉质性状没有观察到显着影响。我们的结果表明,在波兰基于IGF2突变的选择可能对 PL 和 LW 猪非常有用,其中G等位基因仍然相对频繁。
更新日期:2020-09-22
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