The formation of a polygonal configuration of proto-blood-vessels from initially dispersed cells is the first step in the development of the circulatory system in vertebrates. This initial vascular network later expands to form new blood vessels, primarily via a sprouting mechanism. We review a range of recent results obtained with a Monte Carlo model of chemotactically migrating cells which can explain both de novo blood vessel growth and aspects of blood vessel sprouting. We propose that the initial network forms via a percolation-like instability depending on cell shape, or through an alternative contact-inhibition of motility mechanism which also reproduces aspects of sprouting blood vessel growth.

中文翻译：

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血管生长的动力学机制

从最初分散的细胞形成多边形的原始血管结构是脊椎动物循环系统发育的第一步。这个最初的血管网络后来扩展形成新的血管，主要是通过发芽机制。我们回顾了最近使用趋化迁移细胞的蒙特卡罗模型获得的一系列结果，这些模型可以解释血管从头生长和血管发芽的各个方面。我们建议初始网络通过取决于细胞形状的类似渗流的不稳定性形成，或者通过运动机制的替代接触抑制形成，该机制也再现了发芽血管生长的各个方面。