Factor XI (FXI) deficiency is a hereditary coagulation disorder observed in various mammalian species. The molecular basis of coagulopathy has been recognized in Holstein cattle as a 76-bp insertion in the coding region of theFXI gene. Because the disorder seems to have an impact on reproductive traits and udder health in cattle, we tested 103 randomly selected cows, 28 cows with repeat breeding, and 9 cows with recurrent mastitis for the presence of an abnormalFXI allele. Three related cows were diagnosed as carriers.

中文翻译：

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鉴定导致波兰荷斯坦-弗里斯兰牛凝血因子 XI 缺乏的突变携带者。

因子 XI (FXI) 缺乏症是一种在各种哺乳动物中观察到的遗传性凝血障碍。在荷斯坦牛中，凝血病的分子基础被认为是FXI基因编码区中的 76 bp 插入。因为这种疾病似乎对牛的生殖特征和乳房健康有影响，我们测试了 103 头随机选择的奶牛、28 头重复繁殖的奶牛和 9 头复发性乳腺炎的奶牛是否存在异常的FXI等位基因。三头相关奶牛被诊断为携带者。