The aim of this study was to define concentration changes of soluble adhesion molecules (sICAM-1, sVCAM-1 and sE-Selectin) in cerebrospinal fluid and plasma, as well as, number of peripheral blood leukocytes and the albumin coefficient in the patients with the acute brain infarction. We also, analyzed the correlation between the measured levels, the infarct volume and the degree of neurological and the functional deficit. The study included 50 patients with the acute cerebral infarction and the control group consisted of 16 patients, age and sex matched. Obtained results showed significant increase in number of leukocytes, the albumin coefficient and the level of soluble adhesion molecules within the first seven days in patients. The highest values of measured parameters were noted within the third and the fourth day after the insult, which is the suggested period of maximal intensity of inflammatory reactions. Significant correlation was found between measured parameters and the infarct volume, the degree of neurological and the functional deficit. The results suggest that investigated parameters in CSF and blood represent a dynamic index of inflammatory events as one of the fundametal mechanisms responsible for neuron damage during acute phase of brain infarction.

中文翻译：

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急性脑梗死患者脑脊液和血浆中可溶性粘附分子的时间模式。

本研究的目的是确定脑脊液和血浆中可溶性粘附分子（sICAM-1、sVCAM-1 和 sE-Selectin）的浓度变化，以及外周血白细胞数量和白蛋白系数。急性脑梗塞。我们还分析了测量水平、梗死体积与神经和功能缺陷程度之间的相关性。该研究包括 50 名急性脑梗死患者，对照组由 16 名年龄和性别匹配的患者组成。获得的结果显示，患者在前 7 天内的白细胞数量、白蛋白系数和可溶性粘附分子水平显着增加。测量参数的最高值出现在侮辱后的第三天和第四天，这是炎症反应最大强度的建议时期。在测量参数与梗塞体积、神经系统和功能缺陷的程度之间发现了显着的相关性。结果表明，脑脊液和血液中的研究参数代表了炎症事件的动态指数，作为导致脑梗塞急性期神经元损伤的基本机制之一。