In our environment, we have numerous chances to be exposed to not only static magnetic fields (SMFs) but also many chemicals containing mutagens. Therefore, the aim of this study was to investigate the effects of co-exposure to SMF and cadmium (Cd) on the antioxidant enzymes activity and DNA damage in pregnant rat tissues. Pregnant rats were treated with cadmium (CdCl2, 3.0 mg/Kg body weight) or exposed to SMF (128 mT/h/day) and treated with cadmium chlorides (3.0 mg/kg, body weight) for 13 consecutive days as from the 6th to 19th day of gestation. Cd treatment increased malondialdehyde (MDA) and 8-oxodGuo levels in kidney of pregnant rats. However, the activity of superoxide dismutase (SOD) and glutathione level were decreased in kidney. Interestingly, the combined effects of SMF and Cd have no effects on activities of antioxidant in both tissues compared to cadmium treated group. However, the association between SMF and Cd decreased plasma MDA concentration. The same treatment failed to alter 8-oxodGuo concentration. Sub-acute Cd treatment altered antioxidant enzymes and DNA in kidney of pregnant rats. The results suggest that a homeostatic defence mechanism was activated when SMF was associated to Cd in pregnant rats.

中文翻译：

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静磁场对镉毒性的影响：妊娠大鼠组织氧化应激和 DNA 损伤的研究

在我们的环境中，我们有很多机会不仅会暴露在静磁场 (SMF) 中，还会暴露在许多含有诱变剂的化学物质中。因此，本研究的目的是研究同时暴露于 SMF 和镉 (Cd) 对怀孕大鼠组织中抗氧化酶活性和 DNA 损伤的影响。从第 6 天起连续 13 天用镉（CdCl2，3.0 毫克/公斤体重）或暴露于 SMF（128 mT/h/天）和氯化镉（3.0 毫克/公斤体重）治疗怀孕大鼠到怀孕第19天。镉处理增加了怀孕大鼠肾脏中丙二醛 (MDA) 和 8-oxodGuo 的水平。然而，肾脏中超氧化物歧化酶（SOD）的活性和谷胱甘肽水平降低。有趣的是，与镉处理组相比，SMF 和 Cd 的联合作用对两种组织中的抗氧化活性没有影响。然而，SMF 和 Cd 之间的关联降低了血浆 MDA 浓度。相同的处理未能改变 8-oxodGuo 的浓度。亚急性镉处理改变了怀孕大鼠肾脏中的抗氧化酶和 DNA。结果表明，当 SMF 与怀孕大鼠的 Cd 相关时，体内平衡防御机制被激活。