Gastrointestinal bacteria, like Escherichia coli, must remove bile acid to survive in the gut. Bile acid removal in E. coli is thought to be mediated primarily by the multidrug efflux pump, AcrB. Here, we present the structure of E. coli AcrB in complex with deoxycholate at 3.85 A resolution. All evidence suggests that bile acid is transported out of the cell via the periplasmic vestibule of the AcrAB-TolC complex.

中文翻译：

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与胆汁酸复合的外排泵AcrB的结构。

胃肠道细菌，如大肠杆菌，必须除去胆汁酸才能在肠道中存活。人们认为，大肠杆菌中胆汁酸的去除主要是由多药外排泵AcrB介导的。在这里，我们介绍了在3.85 A分辨率下与脱氧胆酸盐复合的大肠杆菌AcrB的结构。所有证据表明胆汁酸是通过AcrAB-TolC复合体的周质前庭转运出细胞的。