Oxidative stress in atrial tissue may be causally related to atrial fibrillation as suggested by clinical and animal studies. Reactive oxygen species (ROS) are known to play a key role in fibrosis and the induction of after-depolarization and triggered activity. Therefore, suppressing oxidative stress may have a potential beneficial role in the management of atrial fibrillation. Since increased NADPH oxidase activity is shown to play a key role in generation of ROS in atrial tissue and in atrial fibrillation, our proposed strategy to target upstream inhibition of ROS production by inhibition of NADPH oxidase activity may provide a novel approach to prevent atrial fibrillation recurrences. We hypothesize that apocynin could be effective against atrial fibrillation, by virtue of its potent inhibitory effect of a major oxidative system (i.e. NADPH oxidase) combined with its demonstrated anti-inflammatory, antifibrotic and antihypertensive effects which partially are driven from its antioxidant property. Atrial fibrillation is known to be initiated by the interaction of these multiple factors.

中文翻译：

---

Apocynin：一种有效的NADPH氧化酶抑制剂，用于控制房颤。

如临床和动物研究表明，心房组织中的氧化应激可能与房颤有关。已知活性氧（ROS）在纤维化以及后去极化和触发活动的诱导中起关键作用。因此，抑制氧化应激可能在房颤的管理中具有潜在的有益作用。由于显示出增加的NADPH氧化酶活性在心房组织和房颤中ROS的产生中起关键作用，因此我们提出的通过抑制NADPH氧化酶活性来靶向抑制ROS产生的上游策略可能提供了一种预防心房颤动复发的新方法。 。我们推测，由于其对主要氧化系统的有效抑制作用，载脂蛋白（Apocynin）可以有效对抗房颤。NADPH氧化酶）与已证明的抗炎，抗纤维化和降压作用相结合，部分原因是其抗氧化特性。已知房颤是由这些多种因素的相互作用引起的。