In an attempt to search for more potent positive inotropic agents, a series of 2‐(4‐(4‐substituted benzyloxy)‐3‐methoxybenzyl)‐1,4‐diazepan‐1‐yl)‐N‐(4,5‐dihydro‐1‐methyl[1,2,4]triazolo[4,3‐a]quinolin‐7‐yl)acetamides was synthesized and their positive inotropic activities were evaluated by measuring left atrium stroke volume on isolated rabbit‐heart preparations. Several compounds showed favorable activity compared with the standard drug Milrinone among which 2‐(4‐(4‐(2‐chlorobenzyloxy)‐3‐methoxybenzyl)‐1,4‐diazepan‐1‐yl)‐N‐(4,5‐dihydro‐1‐methyl‐[1,2,4]triazolo[4,3‐a]quinolin‐7‐yl)acetamide 6e was found to have the most desirable potency with the 6.79 ± 0.18% increased stroke volume (Milrinone: 1.67 ± 0.64%) at a concentration of 1×10–5 M in our in‐vitro study. The chronotropic effects of those compounds having inotropic effects were also evaluated in this work.

中文翻译：

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2-(4-(4-取代苄氧基)-3-甲氧基苄基)-1,4-二氮杂-1-基)-N-(4,5-二氢-1-甲基[1,2]的合成和正性肌力评估,4]三唑并[4,3-a]喹啉-7-基)-乙酰胺

为了寻找更有效的正性肌力药物，一系列 2-(4-(4-取代苄氧基)-3-甲氧基苄基)-1,4-diazepan-1-yl)-N-(4,5-合成了二氢-1-甲基[1,2,4]三唑并[4,3-a]喹啉-7-基）乙酰胺，并通过测量离体兔心脏制剂的左心房每搏输出量来评估它们的正性肌力活性。与标准药物米力农相比，几种化合物表现出良好的活性，其中 2-(4-(4-(2-氯苄氧基)-3-甲氧基苄基)-1,4-二氮杂-1-基)-N-(4,5-二氢-1-甲基-[1,2,4]三唑并[4,3-a]喹啉-7-基)乙酰胺6e被发现具有最理想的效力，每搏输出量增加6.79±0.18%（米力农：1.67 ± 0.64%) 在我们的体外研究中浓度为 1×10–5 M。