Signaling through nuclear factor-kappa B (NF-kappaB) is emerging as an important regulator of muscle development, maintenance, and regeneration. Classic signaling modulates early muscle development by enhancing proliferation and inhibiting differentiation, and alternative signaling promotes myofiber maintenance and metabolism. Likewise, NF-kappaB signaling is critical for the development of immunity. Although these processes occur normally, dysregulation of NF-kappaB signaling has prohibitive effects on muscle growth and regeneration and can perpetuate inflammation in muscle diseases. Aberrant NF-kappaB signaling from immune and muscle cells has been detected and implicated in the pathologic progression of numerous dystrophies and myopathies, indicating that targeted NF-kappaB inhibitors may prove clinically beneficial.

中文翻译：

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骨骼肌疾病，炎症和NF-κB信号传导：治疗干预的见解和机会。

通过核因子-κB（NF-kappaB）发出的信号正在成为肌肉发育，维持和再生的重要调节剂。经典信号通过增强增殖和抑制分化来调节早期肌肉的发育，而其他信号则促进肌纤维的维持和代谢。同样，NF-κB信号传导对免疫力的发展至关重要。尽管这些过程正常发生，但NF-κB信号转导的失调对肌肉的生长和再生具有抑制作用，并可能使肌肉疾病中的炎症永存。已检测到来自免疫细胞和肌肉细胞的异常NF-kappaB信号传导，并与许多营养不良和肌病的病理进展有关，这表明靶向NF-kappaB抑制剂可能在临床上证明是有益的。