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Targeting NF-kappaB: a promising molecular therapy in inflammatory arthritis.
International Reviews of Immunology ( IF 5 ) Pub Date : 2008-10-15 , DOI: 10.1080/08830180802295740
Jorge A Roman-Blas 1 , Sergio A Jimenez
Affiliation  

The nuclear factor-kappa B family of transcription factors is intimately involved in the regulation of the inflammatory responses that play a fundamental role in the damage of articular tissues. Thus, many studies have examined the important contributions of components of the NF-kappaB signaling pathways to the pathogenesis of various rheumatic diseases and their pharmacologic modulation. Currently available therapeutic agents including nonsteroidal anti-inflammatory drugs, corticosteroids, nutraceuticals, and disease-modifying antirheumatic drugs, as well as novel specific small-molecule inhibitors have been employed. In addition, promising nucleic acid-based strategies have shown encouraging results. However, further research will be needed before NF-kappaB-aimed strategies become an effective therapy for inflammatory arthritis.

中文翻译:

靶向NF-κB:炎性关节炎中一种有前途的分子疗法。

转录因子的核因子-κB家族与炎症反应的调节密切相关,所述炎症反应在关节组织的损伤中起基本作用。因此,许多研究已经检查了NF-κB信号传导途径的成分对各种风湿性疾病的发病机理及其药理作用的重要贡献。目前已经使用的治疗剂包括非甾体抗炎药,皮质类固醇,营养保健药和减轻疾病的抗风湿药,以及新型的特异性小分子抑制剂。另外,有前途的基于核酸的策略显示出令人鼓舞的结果。但是,在以NF-κB为靶点的策略成为炎性关节炎的有效疗法之前,还需要进一步的研究。
更新日期:2019-11-01
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