The nuclear factor (NF)-kappa B family of proteins is a key regulator of inflammation, innate immunity, and cell survival and differentiation. Components of these pathways are potential targets of intervention for inflammation, infectious diseases, and cancer. However, therapeutic interventions that dampen the host response to infection and injury must also recognize the autoregulatory loops in the "resolution" phase of inflammation and infection. A more precise fine-tuning of these pathways leading to NF-kappaB activation will require dissecting temporally the different phases of activation and endogenous autoregulatory deactivation programs in diseases and redefining end-points after drug/inhibitor treatment to correlate changes in these stages.

中文翻译：

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核因子-κB：微调各种生物刺激的中央整合器。

蛋白质的核因子（NF）-κB家族是炎症，先天免疫以及细胞存活和分化的关键调节剂。这些途径的组成部分可能是炎症，传染病和癌症干预的潜在目标。但是，抑制宿主对感染和损伤反应的治疗性干预措施也必须认识到炎症和感染“消退”阶段的自调节循环。这些导致NF-κB激活的途径的更精确的微调将需要在时间上剖析疾病激活和内源性自动调节失活程序的不同阶段，并在药物/抑制剂治疗后重新定义终点以关联这些阶段的变化。