The C2H2 zinc finger is one of the most common domains encoded by animal genomes and has been implicated in DNA binding as well as protein-protein interactions and RNA binding. Genes encoding C2H2 zinc finger domains include not only well-studied conserved transcription factors such as Gli and Snail but also include a large diversity of more rapidly evolving genes. Here, I focus on the description of amphioxus members of families and super-families of C2H2 zinc finger genes that have been the subject of functional studies in other species, specifically the Gli, Zic, Glis, Snail, Scratch, Krox, Wilms' tumour, Huckebein, SP, KLF, Ovo, Spalt, Blimp-1, Odd and Fez genes. Surveys of the Branchiostoma floridae genome reveal members of all of these groups of genes. Genes are named according to molecular phylogenetic analyses, such that the nomenclature reflects pre-existing gene names in the context of gene families that have descended from a single common ancestral gene in the common ancestor of chordates and insects. In total, this comprises 28 B. floridae C2H2 zinc finger genes, representing at least 15 gene families. For 17 of these genes, expressed sequence tag clusters and associated clone identification codes relating to the B. floridae gene collection are given.

中文翻译：

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Gli、Zic、KLF、SP、Wilms' tumour、Huckebein、Snail、Ovo、Spalt、Odd、Blimp-1、Fez 的 C2H2 锌指基因和来自 Branchiostoma floridae 的相关基因家族。

C2H2 锌指是动物基因组编码的最常见结构域之一，与 DNA 结合以及蛋白质-蛋白质相互作用和 RNA 结合有关。编码 C2H2 锌指结构域的基因不仅包括经过充分研究的保守转录因子，如 Gli 和 Snail，还包括大量多样性的更快速进化的基因。在这里，我重点描述了 C2H2 锌指基因的家族和超家族成员的描述，这些基因已经成为其他物种功能研究的主题，特别是 Gli、Zic、Glis、Snail、Scratch、Krox、Wilms 肿瘤、Huckebein、SP、KLF、Ovo、Spalt、Blimp-1、Odd 和 Fez 基因。佛罗里达州鳃孔虫基因组的调查揭示了所有这些基因组的成员。基因根据分子系统发育分析命名，这样命名法反映了在基因家族的背景下预先存在的基因名称，这些基因家族是从脊索动物和昆虫的共同祖先中的一个共同祖先基因产生的。这总共包含 28 个 B. floridae C2H2 锌指基因，代表至少 15 个基因家族。对于这些基因中的 17 个，给出了与 B. floridae 基因集合相关的表达序列标签簇和相关克隆识别代码。