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Evolution, population structure, and phylogeography of genetically monomorphic bacterial pathogens.
Annual Review of Microbiology ( IF 10.5 ) Pub Date : 2008-09-13 , DOI: 10.1146/annurev.micro.62.081307.162832 Mark Achtman 1
Annual Review of Microbiology ( IF 10.5 ) Pub Date : 2008-09-13 , DOI: 10.1146/annurev.micro.62.081307.162832 Mark Achtman 1
Affiliation
Genetically monomorphic bacteria contain so little sequence diversity that sequencing a few gene fragments yields little or no information. As a result, our understanding of their evolutionary patterns presents greater technical challenges than exist for genetically diverse microbes. These challenges are now being met by analyses at the genomic level for diverse types of genetic variation, the most promising of which are single nucleotide polymorphisms. Many of the most virulent bacterial pathogens are genetically monomorphic, and understanding their evolutionary and phylogeographic patterns will help our understanding of the effects of infectious disease on human history.
中文翻译:
基因单态细菌病原体的进化,种群结构和系统地理学。
遗传单态细菌几乎没有序列多样性,以至于对几个基因片段进行测序几乎不会产生任何信息。结果,我们对它们的进化模式的理解提出了比遗传多样的微生物更大的技术挑战。现在,通过在基因组水平上分析各种类型的遗传变异来应对这些挑战,其中最有希望的是单核苷酸多态性。许多最剧毒的细菌病原体在基因上是单态的,了解它们的进化和系统地理学模式将有助于我们了解传染病对人类历史的影响。
更新日期:2019-11-01
中文翻译:
基因单态细菌病原体的进化,种群结构和系统地理学。
遗传单态细菌几乎没有序列多样性,以至于对几个基因片段进行测序几乎不会产生任何信息。结果,我们对它们的进化模式的理解提出了比遗传多样的微生物更大的技术挑战。现在,通过在基因组水平上分析各种类型的遗传变异来应对这些挑战,其中最有希望的是单核苷酸多态性。许多最剧毒的细菌病原体在基因上是单态的,了解它们的进化和系统地理学模式将有助于我们了解传染病对人类历史的影响。