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Transgenerational epigenetic effects.
Annual Review of Genomics and Human Genetics ( IF 8.7 ) Pub Date : 2008-09-05 , DOI: 10.1146/annurev.genom.9.081307.164445
Neil A Youngson 1 , Emma Whitelaw
Affiliation  

Transgenerational epigenetic effects include all processes that have evolved to achieve the nongenetic determination of phenotype. There has been a long-standing interest in this area from evolutionary biologists, who refer to it as non-Mendelian inheritance. Transgenerational epigenetic effects include both the physiological and behavioral (intellectual) transfer of information across generations. Although in most cases the underlying molecular mechanisms are not understood, modifications of the chromosomes that pass to the next generation through gametes are sometimes involved, which is called transgenerational epigenetic inheritance. There is a trend for those outside the field of molecular biology to assume that most cases of transgenerational epigenetic effects are the result of transgenerational epigenetic inheritance, in part because of a misunderstanding of the terms. Unfortunately, this is likely to be far from the truth.

中文翻译:

跨代表观遗传效应。

跨代表观遗传效应包括已发展为实现表型的非遗传确定的所有过程。进化生物学家对此领域一直有长期兴趣,他们将其称为非孟德尔遗传。跨代表观遗传效应包括跨代信息的生理和行为(智力)传递。尽管在大多数情况下根本不了解其潜在的分子机制,但有时会涉及通过配子传给下一代的染色体的修饰,这称为跨代表观遗传。对于分子生物学领域以外的人们,有一种趋势是,大多数的后代表观遗传效应都是由后代表观遗传遗传产生的,部分是由于对术语的误解。不幸的是,这可能与事实相去甚远。
更新日期:2019-11-01
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