Experimental autoimmune uveoretinitis (EAU) serves as an animal model for human uveitis. EAU is inducible in animals by peripheral immunization with proteins found in the retina that triggers an immune response which leads to tissue damage. This is coordinated by autoantigen specific CD4(+) T cells whose activation is accompanied by the infiltration of a wide range of other leukocytes into the retina. Infiltrating macrophages and granulocytes cause destruction by the release of reactive oxygen and nitrogen species but these and other leukocytes also regulate inflammation. This review will describe the dynamics of leukocyte infiltration in EAU from the initial systemic activation of T cells following immunization, through their traffic into the eye causing a peak of infiltration, and ending with a phase of secondary regulation in which, although clinical disease has resolved, the leukocyte composition of the eye remains altered.

中文翻译：

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实验性自身免疫性葡萄膜视网膜炎中白细胞浸润的动力学。

实验性自身免疫性葡萄膜视网膜炎（EAU）可作为人类葡萄膜炎的动物模型。通过用视网膜中发现的蛋白质进行周边免疫可以诱导动物产生EAU，从而触发免疫反应，从而导致组织损伤。这是由自身抗原特异性CD4（+）T细胞协调的，其活化伴随着大量其他白细胞浸润到视网膜中。浸润的巨噬细胞和粒细胞通过释放活性氧和氮而引起破坏，但是这些和其他白细胞也调节炎症。这篇综述将描述从免疫后T细胞最初的全身性激活开始，到进入眼睛的T细胞进入眼睛的过程，并最终达到二级调节阶段，EAU中白细胞浸润的动态。