Retroviruses are highly successful intracellular parasites, and as such they are found in nearly all branches of life. Some are relatively benign, but many are highly pathogenic and can cause either acute or chronic diseases. Therefore, there is tremendous selective pressure on the host to prevent retroviral replication, and for this reason cells have evolved a variety of restriction factors that act to inhibit or block the viruses. This review is a survey of the best-characterized restriction factors capable of inhibiting retroviral replication and aims to highlight the diversity of strategies used for this task.

中文翻译：

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阻止逆转录病毒复制的宿主限制因素。

逆转录病毒是非常成功的细胞内寄生虫，因此它们几乎存在于生命的所有分支中。有些是相对良性的，但许多是高致病性的，可引起急性或慢性疾病。因此，宿主面临着阻止逆转录病毒复制的巨大选择压力，因此细胞进化出多种限制因子来抑制或阻断病毒。本综述是对能够抑制逆转录病毒复制的最佳特征限制因子的调查，旨在强调用于该任务的策略的多样性。