Progress in aging research is now rapid, and surprisingly, studies in a single-celled eukaryote are a driving force. The genetic modulators of replicative life span in yeast are being identified, the molecular events that accompany aging are being discovered, and the extent to which longevity pathways are conserved between yeast and multicellular eukaryotes is being tested. In this review, we provide a brief retrospective view on the development of yeast as a model for aging and then turn to recent discoveries that have pushed aging research into novel directions and also linked aging in yeast to well-developed hypotheses in mammals. Although the question of what causes aging still cannot be answered definitively, that day may be rapidly approaching.

中文翻译：

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酵母的复制老化：达到目的的手段。

目前，衰老研究进展迅速，令人惊讶的是，单细胞真核生物的研究是推动力。酵母复制寿命的遗传调节因子正在被识别，伴随衰老的分子事件正在被发现，并且长寿途径在酵母和多细胞真核生物之间的保守程度正在被测试。在这篇综述中，我们对酵母作为衰老模型的发展进行了简要回顾，然后转向最近的发现，这些发现将衰老研究推向了新的方向，并将酵母的衰老与哺乳动物中成熟的假设联系起来。尽管衰老的原因仍然无法得到明确的答案，但那一天可能很快就会到来。