Post-translational modifications of histones are the subject of intensive investigations with the aim of decoding how they regulate, alone or in combination, chromatin structure, genomic stability, and gene expression. Major epigenetic programming events take place during gametogenesis and fetal development and are thought to have long-lasting consequences on adult health. Epidemiological and experimental studies have pointed toward maternal nutrition as a major player during prenatal development in influencing disease susceptibility later in life. Although the mechanisms underlying such observations are not well elucidated, epigenetic alterations of histones by particular maternal diets might be of central importance. Moreover, as much as dietary sources can influence epigenetic programming during pregnancy, they have started to be implicated in cancer chemoprevention, via the targeting of reversible epigenetic deregulations at the level of the histones.

中文翻译：

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组蛋白结构和功能的饮食控制。

组蛋白的翻译后修饰是深入研究的主题，目的是解码它们如何单独或组合调节染色质结构、基因组稳定性和基因表达。主要的表观遗传编程事件发生在配子发生和胎儿发育期间，被认为对成人健康具有长期影响。流行病学和实验研究表明，母体营养是产前发育过程中影响生命后期疾病易感性的主要参与者。尽管此类观察的潜在机制尚未得到很好的阐明，但特定母体饮食对组蛋白的表观遗传改变可能具有重要意义。此外，尽管饮食来源可以影响怀孕期间的表观遗传编程，