The Fusarium mycotoxin deoxynivalenol (DON) facilitates fungal spread within wheat tissue and the development of Fusarium head blight disease. The ability of wheat spikelets to resist DON-induced bleaching is genotype-dependent. In wheat cultivar (cv.) CM82036 DON resistance is associated with a quantitative trait locus, Fhb1, located on the short arm of chromosome 3B. Gene expression profiling (microarray and real-time RT-PCR analyses) of DON-treated spikelets of progeny derived from a cross between cv. CM82036 and the DON-susceptible cv. Remus discriminated ten toxin-responsive transcripts associated with the inheritance of DON resistance and Fhb1. These genes do not exclusively map to Fhb1. Based on the putative function of the ten Fhb1-associated transcripts, we discuss how cascades involving classical metabolite biotransformation and sequestration processes, alleviation of oxidative stress and promotion of cell survival might contribute to the host response and defence against DON.

中文翻译：

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与小麦对镰刀菌毒素脱氧雪腐镰刀菌烯醇的基因型依赖性反应相关的基因网络的组成部分。

镰刀菌毒素脱氧雪腐镰刀菌烯醇 (DON) 促进真菌在小麦组织内的传播和镰刀菌枯萎病的发展。小麦小穗抵抗 DON 诱导的白化的能力是基因型依赖性的。在小麦品种 (cv.) CM82036 中，DON 抗性与位于染色体 3B 短臂上的数量性状基因座 Fhb1 相关。DON 处理的子代小穗的基因表达谱（微阵列和实时 RT-PCR 分析）来自 cv. CM82036 和 DON 敏感的 cv。Remus 区分了 10 个与 DON 抗性和 Fhb1 遗传相关的毒素响应转录物。这些基因不完全映射到 Fhb1。基于十个 Fhb1 相关转录本的假定功能，