The role of the transcription factor NF-kappa B, particularly its coupling to inflammation and cancer, has generated considerable interest in recent years. NF-kappa B in the skin is crucial for morphogenesis and homeostasis. Perturbations in its activity are linked to developmental skin defects, inflammatory skin disease, and skin cancer. However, the most striking aspect of NF-kappa B function in the skin is its two-faced behavior--both activation and inhibition of the pathway causes inflammation. In this review, we focus on the role of NF-kappa B in the skin and summarize the current knowledge in the field arising from animal models as well as human disease studies.

中文翻译：

---

皮肤中的两面NF-κB。

近年来，转录因子NF-κB的作用，特别是其与炎症和癌症的偶联，引起了人们的极大兴趣。皮肤中的NF-κB对于形态发生和体内平衡至关重要。其活动的扰动与发育性皮肤缺陷，炎性皮肤病和皮肤癌有关。然而，皮肤中NF-κB功能最显着的方面是它的两方面行为-激活和抑制该途径都会引起炎症。在这篇综述中，我们重点关注NF-κB在皮肤中的作用，并总结了动物模型以及人类疾病研究领域的最新知识。