Phosphatidylinositol 4,5-bisphosphate (PIP2) is a minority phospholipid of the inner leaflet of plasma membranes. Many plasma membrane ion channels and ion transporters require PIP2 to function and can be turned off by signaling pathways that deplete PIP2. This review discusses the dependence of ion channels on phosphoinositides and considers possible mechanisms by which PIP2 and analogues regulate ion channel activity.

中文翻译：

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PIP2 是离子通道功能的必要辅助因子：如何以及为什么？

磷脂酰肌醇 4,5-二磷酸 (PIP2) 是质膜内小叶的少数磷脂。许多质膜离子通道和离子转运蛋白需要 PIP2 才能发挥作用，并且可以通过消耗 PIP2 的信号通路关闭。本综述讨论了离子通道对磷酸肌醇的依赖性，并考虑了 PIP2 和类似物调节离子通道活性的可能机制。